RMI 4
In 1990, Jacobs et al. proposed a risk of malignancy index (RMI) by combining the values of CA125, ultrasound, and menopausal status. This algorithm has been used clinically for a long time in three different versions (RMI I, II and III). By 2009 Yamamoto et al. introduced RMI version IV with a cut-off value of 450